https://github.com/seb-m/pyinotify/pull/153

Index: python3/pyinotify.py
--- python3/pyinotify.py.orig
+++ python3/pyinotify.py
@@ -211,6 +211,11 @@ class _CtypesLibcINotifyWrapper(INotifyWrapper):
         except (OSError, IOError):
             pass  # Will attemp to load it with None anyway.
 
+        # Special handling for OpenBSD where the library is
+        # installed in a subdirectory.
+        if sys.platform.startswith('openbsd'):
+            libc_name = '${LOCALBASE}/lib/inotify/libinotify.so'
+
         self._libc = ctypes.CDLL(libc_name, use_errno=True)
         self._get_errno_func = ctypes.get_errno